Solve Biochemistry AIIMS 2019 1. Which of the following does not happen in 5' to 3' direction? Transcription DNA repair RNA editing DNA replication None 2. Which of the following TCA cycle intermediate is a part of heme metabolism? Alpha ketoglutarate Succinyl CoA Fumarate Malate None 3. Child presents with hypotonia and seizures. It was confirmed to be Zellweger syndrome. Which among the following accumulates in brain in this condition? Long chain fatty acid Glucose Lactic acid Triglycerides None 4. The catalytic efficiency of the enzyme is best expressed by which of the following kinetic constants Kcat/Km Km/Ka Km/Kcat Ka/Km None 5. Type of mutation seen in sickle cell anemia: Frameshift mutations Insertion Deletion Point mutation None 6. Chimeric DNA is used for: Paternity test Maternity test Organ transplantation Personal identification None 7. By which mechanism does gene repair occur when mediated by CRISPR-Cas9? Non-Homologous End Joining Homologous End Joining Base excision Mismatch repair None 8. Which of the following is deficient in a patient with features as shown below: Arginine Tryptophan Phenylalanine Glutamine None 9. A bodybuilder starts eating raw eggs for protein. He starts to develop fatigue on moderate exercise. The doctor prescribes a vitamin. Which enzyme is deficient in him? Pyruvate Carboxylase PEPCK Glucose 6 Phosphate Glycogen Phosphorylase None 10. The attachment of Eukaryotic mRNA to the ribosome is mediated through tRNA Poly A tail Shine-Dalgarno Sequence Guanyl Cap None 11. Which of the following would have no effect on the function of the protein product? Glutamine replaced by glutamate Glutamine replaced by alanine Glutamine replaced by arginine Glutamine replaced by asparagine None 12. Which of the following is not true about of proteoglycans? Carries negative charge Chondroitin sulfate is a proteoglylcan Holds less water Made of amino acids and sugars None 13. Which of the following shows functional assessment of B1 deficiency? RBC Transketolase RBC Glutathione reductase RBC Glutathione Peroxidase Serum Thiamine levels None 14. Which of the following has protective as well as lubricating properties? Albumin Immunoglobulin Collagen Mucin None 15. Restriction endonuclease will act on which of the following: AAGAAG GAGAGG TACGAG AAGCTT None 16. Which modification will lead to a change in the biological activity of the hormone given in the picture? Hydrolysis of disulphide bonds Change in 29-30 in B chain Change in 5-6 in A chain Change in 14-16 in A chain None 17. In urea cycle disorders, which of the following can be used to reduce the levels of ammonia? Glutamate Phenylbutyrate L-carnitine Phenylbutyrate None 18. The graph shown below is the titration curve of a biochemical compound. Which of the following statement is true? Points A and B represent the range of maximum ionization of the amine and carboxyl group The compound has one ionizable group The compound has three ionizable side chains The maximum buffering capacity of the compound is represented by points A and B None 1 out of 18 Time's up
