Solve Pathology INICET 2021 1. A person working in an industry for a long time developed progressive breathlessness. The histopathological image of his lung biopsy is given below. What industry was he most likely working in? Coal dust Silica Cotton Asbestos None 2. A patient presented with complaints of dyspnea on exertion for 1 month. Echocardiography showed the presence of mitral stenosis and left ventricular hypertrophy. Identify the histopathological finding given below and the probable diagnosis. Calcification of valve; Mitral stenosis Granuloma; Sarcoidosis Non-caseating granuloma; Tuberculosis Aschoff body; Rheumatic heart disease None 3. What is the cell of origin of Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma? Mature T cells Mature B cells Progenitor T cells Naive B cells None 4. A patient with lytic lesions on the skull is suspected of a diagnosis of Langerhans cell histiocytosis. Which of the following is a characteristic finding of electron microscopy? Eosinophils Histiocytes Giant cells Birbeck granules None 5. A 60-year-old patient presented with scrotal swelling and ataxia. Which among the following could likely be a cause? Non-Hodgkin lymphoma Hodgkin lymphoma Glioblastoma multiforme Non seminomatous germ cell tumor None 6. Human Papilloma Virus inactivates RB gene by which of the following proteins? E6 E7 L1 L2 None 7. A patient with cirrhosis and ascites presented to you. The gross appearance of his liver is shown below. Which among the following is true about it? Dark areas represent viable liver tissue, and white areas represent necrosis Dark areas represent necrosis, and white areas represent viable liver tissue White areas represent central hepatocytes Dark areas represent peri-portal hepatocytes None 8. In cystic fibrosis, which of the following structure is affected in pancreas? A B C D None 9. A 7-year-old boy came with bilateral cervical lymphadenopathy. What is the probable diagnosis, cell, and virus associated with the image given below? Non-Hodgkin's lymphoma, Reed-Sternberg cell , Epstein-Barr virus Hodgkin's lymphoma, RS cell, EBV Kaposi sarcoma, Giant cell, Human immunodeficiency virus Infectious mononucleosis, RS cell, CMV None 10. Mediators involved in the early phase of type 1 hypersensitivity are? Leukotrienes Mast Cell Neutrophils Prostaglandins Histamine 1, 2, 3, 4, 1, 2, 4, 5 1,5 2, 3, 4 None 11. A person was brought to the emergency department with facial swelling, itching, and hypotension following a bee sting. The mentioned clinical features are due to the increase in which immunoglobulin? IgG IgM IgA IgE None 12. The vacutainer tube shown in the given image contains: Clot activator NAF-heparin Na-EDTA Trisodium citrate None 13. All of the following are associated with massive splenomegaly except: Chronic myeloid leukemia Lymphoma Hairy cell leukemia Aplastic anemia None 14. Arrange the following cellular events of inflammation in the correct sequence: Cytokine-mediated integrin activation Rolling Migration Adhesion 2, 1, 4, 3 2, 4, 1, 3 1, 2, 3, 4 1, 3, 2, 4 None 15. A 42-year-old female patient presents with cough, low-grade fever, and hemoptysis. Investigations reveal a cavitary lesion on her right lung apex, which on biopsy reveals caseous necrosis. The underlying pathophysiology is: Fibrinoid deposition Type 4 hypersensitivity reaction Enzyme degradation Sudden cut-off of blood supply None 16. Which of the following is used in the treatment of sideroblastic anemia? Vitamin B1 Vitamin B6 Vitamin B12 Iron None 17. A 45-year-old male patient was diagnosed with iron deficiency anemia. Which of the following is true about the intracellular regulation of iron in the above condition? IRE-Iron response elements IRP-Iron regulatory protein  Ferritin translation is increased by binding IRP to IRE Ferritin translation is decreased by binding IRP to IRE Transferrin receptor 1 translation is decreased by binding IRP to IRE Transferrin receptor 1 translation is unaffected by binding IRP to IRE None 18. A 5-year-old child who presented with proptosis of one of the eyes was found to have a desmin-positive tumor. What is the probable diagnosis? Embryonal rhabdomyosarcoma Leukemia Retinoblastoma Ewing's sarcoma None 19. A 65-year-old male patient with chronic fatigue and lymphadenopathy presents to the outpatient department. His peripheral smear shows the presence of smudge cells. Which of the following additional investigations will you do to arrive at a diagnosis? Fluorescent in situ hybridization Polymerase chain reaction Cytogenetics Flow cytometry None 20. A 16-year-old boy presented with intussusception and was taken up for surgery. He was found to have multiple polyps. The resected section was sent for histopathology and the whole mount image of the specimen is given below. Identify the lesion. Hamartomatous polyp Tubulovillous adenoma Hyperplastic polyp Adenocarcinoma None 21. Which of the following is true? HER2neu is amplified only in a fraction of breast cancer. N-MYC is a tumor suppressor gene. BRCA1 is an oncogene. EGFR(+) is seen in non-small cell lung cancer. 1, 4 2, 4 1, 3 1, 2 None 22. Identify the given condition. Leprosy Pemphigus vulgaris Visceral leishmaniasis Mycosis fungoides None 23. A 22-year-old athlete suddenly collapsed while playing football and was taken to the hospital where he was declared dead. His autopsy image is given below. Which of the following is the most likely cause of death? Sudden cardiac death due to arrhythmia Valvular heart disease due to RHD Sudden cardiac death due to Hypertrophic cardiomyopathy Sudden cardiac death due to atherosclerosis None 24. A child presented with bilateral proptosis. From the peripheral smear, he was suspected to have chloroma. What is the next investigation of choice? WBC count Platelet count Flow cytometry Bone marrow biopsy None 25. Which of the following can be prevented by transfusing irradiated RBCs? HLA Alloimmunization Graft versus host disease Transfusion Related Acute Lung Injury (TRALI) Immunomodulation None 26. What is the gold standard investigation for the diagnosis of myocarditis? Magnetic Resonance Imaging Endo-myocardial biopsy LDH1 to LDH2 ratio Brain Natriuretic Peptide None 27. Which of the following statements are correct regarding the effect of Glucose-6-Phosphate Dehydrogenase deficiency? Decreased RBC membrane damage Decreased NADPH Decrease in reduced glutathione Decreased lipid peroxidation 2, 3 1, 2, 3, 4 2, 3, 4 4 None 28. Which of the following is not likely to be seen in a patient with Paroxysmal Nocturnal Hemoglobinuria (PNH)? Leukemia Thrombosis Hemolysis Aplastic anemia None 29. Oil red O stain is used in which of the following? Frozen Section Formalin fixation Alcohol fixation Glutaraldehyde fixation None 1 out of 29 Time's up
