biochemistry pYQ 2017 AIIMS 2017 Solve Biochemistry AIIMS 2017 1. Identify the anaplerotic reaction among the following? Conversion of pyruvate to Oxaloacetate Conversion of pyruvate to Acetyl CoA Conversion of pyruvate to Lactic acid Conversion of pyruvate to Acetaldehyde None 2. Which of the following amino acids is not formed after post-translational modification? Triiodothyronine Hydroxy proline Hydroxylysine Selenocysteine None 3. True regarding Mitochondrial DNA is It codes for more than 25% of oxidative phosphorylation proteins It has a higher mutation rate than nuclear DNA It has 3 X 10^9 base pairs One set from each parent None 4. Which test will be positive in starvation state in urine? Benedict test and heat coagulation test Heat coagulation test Rothera's test Heat coagulation test and Rothera's test None 5. Identify the marked bond: Covalent bond Ionic bond Phosphodiester Bond Hydrogen bond None 6. Which among the following serves as a cofactor for Glycogen phosphorylase: Pyridoxal Phosphate Niacin Thiamine Biotin None 7. Which of the following is Thermogenic food High protein diet High fat diet High carbohydrate diet It does not depend on the macronutrients None 8. Glucosamines are used in which of the following conditions Arthritis Niemann Pick disease Alzheimer's disease Cancer None 9. Which of the following site does the restriction enzyme act when RFLP is used in-order to identify the five different species of staphylococci in a surgical ICU? TAGATA-ATCTCT ATGGAC-TACGTG GATATC-CTATAG AATATA-TATAAT None 10. Which activity does Klenow fragment lacks. 5'->3' Exonuclease 3'->5' Exonuclease 5'->3' DNA polymerase 3'->5' DNA polymerase None 11. Thiamine deficiency results in decreased energy production, because TPP Is coenzyme for pyruvate and alpha ketoglutarate dehydrogenase Interferes with alcohol metabolism Interferes with transketolase activity Interferes with energy production from amino acids None 12. A young patient came with complaints of acute abdominal pain on and off and a tingling sensation of limbs and at times weakness of limbs. She had a history of eating paint from the wall of a newly built house. Which of the following enzyme defect will be the cause of her condition? ALA dehydratase ALA synthase Heme synthase Coproporphyrinogen oxidase None 13. In SCID, what type of DNA repair is defective Base excision repair Non-homologous end-joining repair Mismatch Repair Nucleotide excision repair None 14. Under anaerobic metabolism which of the following substrates yields 3 molecules of ATP? Amino acid Glycogen Glucose Galactose None 15. Which of the following is the reason for using phenylbutyrate in urea cycle disorders? It scavenges nitrogen It maintains renal output It maintains energy production It activates enzymes None 16. A 10-year-old boy rapidly develops hypoglycemia after moderate activity. Blood Investigations reveal raised levels of ketone bodies, lactic acid, and triglycerides. O/E, the liver, and kidneys are found to be enlarged. Histopathology of the liver shows deposits of glycogen in an excess amount. What is the diagnosis? McArdle's disease von Gierke's disease Pompe's disease Cori's disease None 17. Which of the following can alter the gene expression by methylation and acetylation but not change the gene sequence? Epigenetics Mutation Translocation Inversion None 18. Which of the following is not seen in low insulin-glucagon ratio? Glycogen breakdown Ketogenesis Gluconeogenesis Glycogen storage None 19. Which one of the following is not involved in iron metabolism: Transthyretin Transferrin Hepcidin Ceruloplasmin None 1 out of 19 Time's up
