pathology PYQ 2017 AIIMS 2017 Solve Pathology AIIMS 2017 1. A child presents with bilateral proptosis. Which investigation will help you in arriving at a diagnosis of chloroma? Peripheral smear Platelets Hb concentration Leucocytic count None 2. All are reduced in Iron Deficiency Anaemia except Iron Transferrin saturation TIBC Ferritin None 3. A 38-year-old depressed man came with complaints of sudden onset breathlessness, with desaturation. Chest x-ray showed bilateral diffuse infiltrates with predominant involvement of right middle and lower lobes. The patient could not be revived despite treatment. On autopsy, the lungs appeared grossly normal. The histopathology image of the lung is shown below. Which among the following is the appropriate cause? Vegetative matter aspiration pneumonia Necrotizing TB granuloma Severe fungal pneumonia Sarcoid granuloma None 4. What is the function of Acetone free Methanol in Leishman stain? Prevents the cells from sticking to the slide surface Colours the red cells Fixes cells to slide Causes metabolic and enzymatic activity to stop None 5. Which of the following can be used to store blood for up to 35 days? Acid Citrate dextrose Citrate phosphate dextrose Citrate phosphate 2 dextrose Citrate phosphate dextrose adenine - 1 None 6. Identify the correct sequence: Fill the laboratory requisition forms, Identify the Patient, Bedside blood collection, label the samples Label the sample tubes, Bedside blood collection, fill the laboratory requisition forms, Identify the patient Identify the Patient, Fill the laboratory requisition forms, Bedside blood collection, label the samples Bedside blood collection, label the samples, fill the laboratory requisition forms, Identify the patient None 7. A 30-year-old woman presented with painful blisters on the skin and oral mucosa. Direct immunofluorescence is given below. Which of the following is false regarding the same? Suprabasal acantholytic blister is a characteristic feature Antibodies against desmoglein 1 Antibodies against desmoglein 3 Antibodies against hemidesmosomes None 8. Which anticoagulant is used for electrolyte estimation? EDTA Sodium Fluoride Citrate Lithium Heparin None 9. When you add calcium and thromboplastin to platelet poor plasma which pathway is assessed? Intrinsic Extrinsic Common Fibrinolysis None 10. The stain done on a section of the liver shown below is: Steiner silver stain Sweet's reticulin stain Grimelius silver stain Warthin starry stain None 11. Origin of B cell in CLL/SLL is: Bone Marrow Progenitors Naive B cells in Interfollicular zones Extranodal mature Peripheral B cells Centrocytes None 12. A young boy from a high altitude came with fever and weakness and had the following reports - Hemoglobin 17 g%, TLC is 21,000 with neutrophils 25, lymphocytes 30, eosinophils 5, myelocytes and metamyelocytes 40 in peripheral smear. The next step in the investigation should be JAK mutation Philadelphia chromosome Bone Marrow biopsy with reticulin stain Erythropoietin levels None 13. ALK positivity is seen in which of the following neoplasms: Ewing sarcoma Synovial sarcoma Fibromatosis Inflammatory myofibroblastic tumor None 14. A 40-year-old man presents with complaints of facial puffiness and frothy urine. Given below is the histological image of the condition. What do you think is the diagnosis Membranoproliferative nephritis Dense deposit disease Focal segmental glomerulosclerosis Membranous nephropathy None 15. A 55-year-old man presented with the blurring of vision. Urine examination showed proteinuria. Fundus examination showed dot and blot hemorrhages, microaneurysms, and cotton wool spots. Histopathology of the kidney was as shown below. What is your diagnosis? Focal segmental glomerulosclerosis Renal amyloidosis Kimmelstiel-Wilson disease Lupus nephritis None 16. Which of the following is true regarding the internal iron homeostasis in iron-deficiency anemia? Transferrin receptor 1 iron-responsive elements increases transferrin receptor mRNA concentration and synthesis Ferritin mRNA concentration iron-responsive element increases and ferritin synthesis decreases Ferritin mRNA concentration iron responsive element decreases and ferritin synthesis increases Transferrin receptor 1 iron responsive elements decreases transferrin receptor mRNA concentration and synthesis None 17. If the RB gene is hypophosphorylated, which of the following will happen? Cell cycle will stop at G2 Cell cycle will stop at G1 There will be no effect on cell cycle as RB gene phosphorylation is not needed The cell cycle progresses and cell divides None 18. A 38-year-old patient presented with heartburn and increased salivation. Upper gastrointestinal endoscopy was done, and the biopsy result is shown below. What is the diagnosis? Barrett's esophagus Squamous cell carcinoma Adenocarcinoma Esophagitis None 19. A 14-year-old patient presents with bilateral proptosis. The biopsy from the region shows this pattern. What is the likely diagnosis? Fibromatosis Leiomyoma Schwannoma Rhabdomyosarcoma None 20. A 60-year-old male presented with a history of intractable diarrhea. Based on the histological image shown below which of the following is the most appropriate diagnosis: Leishmaniasis Lymphoma Multiple myeloma Urate nephropathy None 21. A 10-year-old boy with fever, weight loss came to the hospital. On examination, he was pale and had significant lymphadenopathy. The bone marrow histology of the person is as given below. Your diagnosis is? Acute myelomonocytic leukemia Acute monocytic leukemia Acute lymphoblastic leukemia Juvenile myelomonocytic leukemia None 22. A patient has a HbA2 of 3% and HbF of 97%. A peripheral blood smear is taken. Which of the following blood pictures will be seen in this patient? 1 2 3 1, 2 2, 3 1, 3 1, 2, 3 None 23. A 34-year-old female with a history of backache and polyarthralgia was investigated and found to have a nucleolar pattern in IF. Which of the following is the best fit in her case? Genital and oral painful ulcers Glomerulonephritis and heart failure Joint pains with nodules on skin Raynaud phenomenon and sclerodactyly None 24. In breast cancer, FISH for gene amplification will be done based on which of the following IHC staining for Her-2/neu? 1+ 2+ 3+ Gene Amplification is done irrespective of Her 2 Neu status None 25. A young male presented with cervical lymphadenopathy. The biopsy of the lymph node showed RS cells with vague nodule formation and a background of reactive T-lymphocytes. The cells were positive for CD20, LCA, EMA and negative for CD 15 and CD30. What is the diagnosis? CLL T cell rich B cell lymphoma Nodular Lymphocyte predominant Hodgkin Lymphoma Nodular Sclerosis - Hodgkin Lymphoma None 26. A 30-year-old male patient presents with severe dyspnoea. Mitral stenosis with left atrial hypertrophy is seen. Vegetations present on the mitral valve were excised. What is the most likely diagnosis based on the given HPE image? Myxoma Infective endocarditis Rheumatic valvular disease Sarcoidosis None 27. Which of the following is a tool used in gene editing: Gene Xpert Big data CRISPR GWAS None 28. Which of the following Immunohistochemistry marker is used in Cyclin D1 negative Mantle cell lymphoma? ITRA 1 SOX11 MYD88 Annexin V None 29. A 40-year-old presented with a fever. On examination, he had enlarged and ulcerated tonsils. His peripheral blood smear showed lymphocytosis. The monospot test was negative. A tonsillectomy was done and it showed large cells mixed with lymphocytes. The cells were positive for CD20, EBV LMP1, MUM1, and CD 79a. Background cells were positive for CD3. The cells are negative for CD15. Your most probable diagnosis is EBV positive - DLBCL, NOS Hodgkin lymphoma EBV positive mucocutaneous ulcer Infectious mononucleosis None 30. During development, thymic cells recognizing self-antigens are removed to prevent autoimmunity. Which gene among the following is involved in the process? NOTCH1 RB gene CPK gene AIRE (Autoimmune Regulator) None 31. Among the following, which cells have MHC class II? All nucleated cells NK cells Platelets B cells, dendritic cells, mononuclear phagocytes None 32. The scraping of a painless genital ulcer, when stained with Gram stain and viewed under the microscope, shows a gram- negative coccobacillus surrounded by neutrophils. What is your diagnosis? Klebsiella granulomatis Neisseria gonorrhoea Chlamydia trachomatis Hemophilus ducneyi None 33. When papain acts on a molecule of immunoglobulin, which of the following are the end products? 1 Variable chain and 1 constant chain 1 Fc and 2 Fab fragments 2 Fc and 1 FAB fragments 2 Fc and 2Fab fragment None 1 out of 33 Time's up
