pharmacology PYQ 2017 AIIMS 2017 Solve Pharmacology AIIMS 2017 1. Dofetilide belongs to which class of anti-arrhythmic drugs? Class I Class II Class III Class IV None 2. The following table gives BP values before and after administration of drug 'X: What would be the probable mechanism of action of drug 'X'? Â Â Â Â Â Â Â Alpha 1 antagonist and Beta 2 agonist Alpha 1 agonist and Beta 1 agonist Beta 1 agonist and Beta 2 agonist M2 agonist and M3 agonist None 3. How much drug will remain at the end of 6 hours when a patient is given 200 mg drug, 75 mg excreted in 90 min, and if the drug follows first-order kinetics? 12.5 mg 6.25 mg 30.5 mg 50 mg None 4. A patient requires Ceftriaxone 180 mg. You have a 2 ml syringe with 10 divisions per ml. The vial contains 500 mg/5ml of ceftriaxone. How many divisions in the 2 ml syringe will you fill to give 180 mg ceftriaxone? 1.8 18 2 20 None 5. What is the most bactericidal anti-leprotic drug among the given drugs? Ciprofloxacin Amoxicillin Erythromycin Ofloxacin None 6. The drug that decreases the size of the prostate is: Finasteride Sildenafil Tamsulosin Flutamide None 7. Which one of the following is a placebo? Cognitive behavioural therapy Sham surgery Herbal medication with no effect known Physiotherapy None 8. Which of the following is not true about P-glycoprotein? Also known as CD243 Also known as ABCB1 Pgp stands for permeability glycoprotein Also known as MDR2 None 9. A young male developed 5 episodes of loose stools 2 hours after eating in a restaurant. He is afebrile and has mild dehydration. What should be the treatment? Ciprofloxacin, tinidazole and ORS Ciprofloxacin and tinidazole Only ciprofloxacin Only ORS None 10. Which of the following drugs is the absorption increased after a fatty meal? Amphotericin B Ampicillin Aspirin Griseofulvin None 11. A patient with Prinzmetal angina is administered isosorbide mononitrate and is noticed to have symptomatic relief. What is the mechanism of action of nitrate in this case? Decreased diastolic perfusion pressure Reduced cardiac contractility Increased left ventricular end-diastolic volume Endothelium-independent coronary vasodilation None 12. Which one of the following the atropine is not indicated? TIK 20 Parathion Baygon Endrin None 13. A 25-year-old female came for treatment of infertility to OPD. Bromocriptine was prescribed. What could be the possible reason? Hypogonadotropic hypogonadism PCOD Hyperprolactinemia PID None 14. The drug of choice in anaphylactic shock is? Atropine 3 mg Adenosine 6 mg followed by 12 mg IV Adrenaline 1 mg 1/10000 IV Adrenaline 0.5 mg 1/1000 IM None 15. Which is a mood stabilizer with an anti-suicidal role? Lamotrigine Carbamazepine Valproate Lithium None 16. What instruction do you give to a mother who is lactating for drug use? Tell the mother to feed when it is least efficacious No advice as most drugs is not present in breast milk To feed just before the next dose, when the plasma concentration of the drug would be the least Give longer half-life drugs None 17. Which of the following is not an idiosyncratic reaction of carbamazepine? Agranulocytosis Blurred vision Rash Steven Johnson Syndrome None 18. In the case of acute exacerbation of asthma, salbutamol was given, however, there was no improvement, Intravenous corticosteroids and aminophylline were given and the condition improved. What is the probable mechanism by which the corticosteroids would have improved the condition? Corticosteroids indirectly increase the effect of xanthines on adenosine receptors Corticosteroids cause direct bronchodilatation when used with xanthines Corticosteroids increase mucociliary clearance Corticosteroids increase bronchial responsiveness to salbutamol None 19. In a middle-aged diabetic patient with chronic kidney disease stage 5, which of the following drugs can be given safely without altering the dose? Saxagliptin Sitagliptin Vildagliptin Linagliptin None 20. The drug of choice for insomnia in blind people is Zerviate Latanoprostene Tasimelteon Ramelteon None 21. Composition of Lente insulin is: 70% amorphous 30% crystalline 70% crystalline 30% amorphous Another name of NPH insulin 70% crystalline 30% amorphous None 22. Which of the following drugs can be used as an antidote for fibrinolytic therapy? Streptokinase Protamine Heparin e-Aminocaproic acid None 23. Mechanism of action of Oseltamivir as an antiviral agent is: Apoptosis of infected cells Inhibition of RNA-dependent DNA polymerase Neuraminidase inhibition Inhibition of M2 receptor None 24. A male patient who is suffering from a psychotic disorder is on antipsychotic, antidepressant, and antihypertensive treatment. He suddenly developed tachycardia and chest tightness. On investigation he had metabolic acidosis. ECG showed widened QRS complex and prolonged QT interval. Which of the following drugs is responsible for this? Enalapril Amlodipine Amitriptyline Chlorthalidone None 25. A epileptic patient on levetiracetam has been seizure-free for 2 years. But he develops agitation and anger issues interfering with his day-to-day activities as a result of the drug intake. Which of the following measures is to be taken next? Continue levetiracetam since a 5-year seizure free interval is needed Slowly taper the drug over the next 6 months Discontinue the drug as he is seizure free Stop levetiracetam and start on a different anti epileptic None 26. You and your friend plan for a mountain trip for the day after. What medication would you advise him to help with his motion sickness? Scopolamine patch the night before trip Ranitidine tablet before start of trip Dimenhydrinate before start of trip Omeprazole the night before and before start of trip None 27. A drug was given IV at a rate of 1.6mg/min. The clearance of the drug is 640ml/min. The half-life of the drug is 1.8 hours. Calculate the plasma concentration of the drug. 0.002mg/ml 0.006mg/ml 2.99mg/ml 3.88mg/ml None 28. A patient was treated for septicemia with norepinephrine infusion. Which of the following best explains the benefit of this drug? Increases mean arterial blood pressure Increases urine output Bradycardia Tachycardia None 29. Which of the following disease-modifying anti rheumatoid drug increases extracellular adenosine? Lefunamide Sulphasalazine Methotrexate Hydroxychloroquine None 30. Which of the following given indicates the storage of drugs in the tissue? Large volume of distribution Small volume of distribution Excretion in saliva Excretion in urine None 31. What is the mechanism of action of vancomycin? 50s ribosome inhibition Cell membrane inhibition Cell wall synthesis inhibition Peptide synthesis inhibition None 1 out of 31 Time's up
