Solve Biochemistry NEET-PG 2024 1. A patient with a family history of coronary heart disease presented with tendon xanthomas. His lipid profile showed serum LDL to be 280 mg/dL and triglyceride levels was 398 mg/dl. What is the likely defect in this patient? LDL metabolism LDL receptor defect Lipoprotein lipase deficiency VLDL metabolism None 2. A patient underwent gastrectomy for gastric adenocarcinoma. Which of the following vitamins needs to be supplemented in this patient? Vitamin B1 Vitamin A Vitamin D Vitamin B12 None 3. A young female comes to the emergency department after ingesting 10 tablets of Phenobarbital. Which of the following components of the ETC is inhibited by this drug? Complex I to Q Cytochrome I-II Complex IV Succinate - Fe None 4. A mother came back home to see her child suffering from difficulty breathing. The child had contact with rotenone while trying to bathe their pet. The child was taken to the emergency department and she later passed away. Inhibition of which of the following enzymes was the likely cause of her death? Succinate dehydrogenase Cytochrome c reductase Cytochrome oxidase NADH-Q oxidoreductase None 5. A child presents to you with bone pain, hepatosplenomegaly, and pancytopenia. A trephine biopsy aspirate shows the following finding. Which of the following is the most likely enzyme deficient in this patient? Glucocerebrosidase Sphingomyelinase Galactocerebosidase Alpha 1,4-glucosidase None 6. A 10-year-old child from a southern Indian state, hailing from a poor family, presents with rough and scaly skin. The child's diet lacks vegetables and fruits. After treatment with linseed oil, Vitamin A, and Vitamin B, the symptoms subsided. What is the most likely diagnosis? Erythroderma Lichen planus Keratosis pilaris Phrynoderma None 7. A 32-year-old lady comes with complaints of erythematous scaly rash, loose stools, and cognitive dysfunction. The rash involved her forearm, neck, and face. She seems to have difficulty remembering things from the recent past. Her electrolytes are within normal range. She admits to having shifted to a corn-based diet due to economic reasons. Which of the following would improve her symptoms? High dose of IV thiamine Oral Nicotinamide supplementation Stop corn diet High Dose Vitamin C None 8. A patient presents to the emergency department with severe abdominal pain, nausea, and vomiting. The laboratory results show serum triglyceride levels > 2000 mg/dl. Which deficiency could be contributing to the patient's condition? Apolipoprotein B100 Apolipoprotein B48 Apolipoprotein C II Apolipoprotein A I None 9. A 3-month-old child was brought to the clinic with a history of difficulty in feeding and failure to thrive. On examination, the child is floppy, 48 cm in length and weighs 2.8 kg. There is generalized hypotonia, macroglossia and hepatomegaly. The chest x-ray of the child is given below. What is the most likely diagnosis? Pompe's disease Ebstein's anomaly Transposition of great arteries Von- Gierke's disease None 10. A child suffering from phenylketonuria was started on necessary dietary modifications but the neurological symptoms persisted. Phenylalanine hydroxylase levels in the serum are normal. Which of the following enzymes is likely to be deficient in this case? Homogentisate oxidase Tyrosine hydroxylase Dopa decarboxylase Tetrahydrobiopterin synthase None 11. After the age of 12, the boy had an intellectual disability. On examination, fingernail abrasions, excessive biting of lips, and increased levels of serum uric acid were observed. What is the likely diagnosis? Lesch-Nyhan disease Von Gierke syndrome Hurler syndrome Hunter syndrome None 12. A patient presented with multiple yellowish raised plaques on eyelids, xanthomas on the achilles tendon. What is the likely cause for the patient's presentation? Tangier's disease Familial hypercholesterolemia Fabry's disease Xanthomatosis None 13. Which micronutrient is most likely deficient in a patient with the radiographic findings given below along with anemia, neutropenia, depigmented hair and skin? Zinc Iron Copper Fluoride None 14. A neonate was brought with features of lethargy, and poor oral intake. On examination, a cataract was seen. Urine Benedict's test was positive but negative for Glucose. What will be the enzyme deficiency in this condition? Galactokinase Hexokinase Phosphofructokinase Galactose-1-phosphate uridyl transferase None 15. A child presented to the OPD with complaints of fatigue and muscle weakness while exercising. Laboratory investigations found that LCFA oxidation was affected. A muscle biopsy was done which revealed the presence of fat vacuoles. What is the probable diagnosis? LPL defect LDL defect Carnitine deficiency Fatty acid synthase defect None 16. A child presented with recurrent abdominal pain, vomiting, and diarrhea following ingestion of milk-based products. Which enzyme is likely to be deficient? Maltase Lipase Lactase Amylase None 17. A patient diagnosed with a rare homozygous recessive condition presented with ectopia lentis. In the peripheral smear, there was no megaloblastic anemia. Later, he was found to have elevated homocysteine levels in the blood. Which of the following supplementations will help the patient? Pyridoxine Thiamine Riboflavin Biotin None 18. A 3-year-old child is brought to the OPD with complaints of persistent delayed developmental milestones, and hyperpigmented macular lesions on the body which are more pronounced on exposure to sunlight. What is the error in DNA multiplication? DNA mismatch repair Homologous recombination Base excision repair Nucleotide excision repair None Time's up
