Solve Pathology AIIMS 2019 1. If DNA is damaged in the cell cycle, which gene causes cell cycle arrest? Rb K-RAS p53 MYC None 2. A young boy from a high altitude came with fever and weakness and had the following reports - Hemoglobin 17 g%, TLC is 21,000 with neutrophils 25, lymphocytes 30, eosinophils 5, myelocytes and metamyelocytes 40 in peripheral smear. The next step in the investigation should be: JAK mutation Philadelphia chromosome Erythropoietin levels Bone Marrow biopsy with reticulin stain None 3. Which of the following is not a hemostatic agent? Chitosan Zeolite Boric acid Kaolin None 4. Acute inflammatory response is not seen in: Apoptosis Pyroptosis Necroptosis Necrosis None 5. A 36-year-old male with skin-colored umbilicated papules. Microscopy is as shown below. The most likely diagnosis is Verruca vulgaris Herpes virus Molluscum contagiosum Lichen planus None 6. An affected male does not have affected children but an affected female always has affected children. Type of inheritance? Mitochondrial X linked dominant X linked recessive Autosomal recessive None 7. Which of the following is the most common cause of liver failure? Pesticides CC14 Paracetamol Alcohol None 8. Which of the following is not an intermediate filament? Tubulin Vimentin Neurofilament Desmin None 9. Which is the most important light microscopic feature of irreversible cell injury? Ribosomal detachment from endoplasmic reticulum Amorphous densities in mitochondria Cell membrane blebs and loss of microvilli Nuclear changes like pyknosis and karyolysis None 10. Which of the following are features of iron deficiency anemia? TIBC increased, Transferrin saturation decreased, Ferritin decreased TIBC increased, Transferrin saturation decreased, Ferritin increased TIBC increased, Soluble transferrin receptor decreased, Ferritin increased TIBC increased, Ferritin decreased, and Transferrin saturation increased None 11. A 20-year-old male patient is diagnosed with acute myeloid leukemia. The peripheral blood smear picture is given in the image. The cell indicated by the arrow is best described as: Flaming promyelocyte Auer rod Faggot cell Dusky promyelocyte None 12. Which of the following is the major source of plasma von-Willebrand factor? Lymphocytes Macrophages Platelets Endothelial cells None 13. A 60-year-old man died 24 hours after the onset of substernal chest pain radiating to the left arm. On autopsy, an atheromatous plaque was seen obstructing the left anterior descending artery. Which type of calcification is most likely to be seen in this condition? Metastatic with increased serum calcium Dystrophic with increased serum calcium Dystrophic with normal serum calcium Metastatic with normal serum calcium None 14. Which of the following causes vasodilation? Histamine Leukotriene C4 Serotonin Thromboxane A2 None 15. Hepcidin inhibits iron transfer from the enterocyte to the plasma by binding to Transferrin Ferroportin Divalent metal transporter 1 (DMT1) Ferritin None 16. Both intrinsic and extrinsic pathways are seen in: Apoptosis Necrosis Pyroptosis Necroptosis None 17. What is the most likely diagnosis based on the given serum electrophoresis image? Tuberculosis Multiple myeloma Nephrotic syndrome Hepatic cirrhosis None 18. A CKD patient had to undergo dialysis and his Hb was 5.2gm/dL. So two blood transfusions were to be given. The first bag was completed in 2 hours. The second was started and in midway, he developed shortness of breath and hypertension. Vitals were BP-180/120 mmHg and pulse rate - 110/min. What is the cause? Transfusion-related circulatory overload Transfusion-related acute lung injury Febrile non-hemolytic transfusion reaction Allergic None 19. All are small round blue cell tumors except: Hemangioblastoma Neuroblastoma Ewing's sarcoma Retinoblastoma None 20. A patient who receives recurrent transfusions for thalassemia develops fever and chills during this time. There is no evidence of hemolysis. Which of the following measures can decrease the rate of transfusion reactions? Antibiotics Leukoreduced RBCs Irradiation Washed RBCs None 21. Which gene is not involved in SCID? JAK-3 IL-7Ra RAG1 BTK None 22. Maltese cross crystals in the urine are seen in which of the following diseases other than nephrotic syndrome? Friedrich's ataxia Fanconi anemia Fabry's disease Felty syndrome None 23. True about anaphylactoid reaction are all except: IgE mediated Involves degranulation of mast cells Can occur on first exposure Most commonly caused by NSAIDS None 24. Basophils are activated by: IL-5 INF-gamma IL-2 TNF-alpha None 25. Which transporter is required for the transport of iron into the enterocyte? Ferroportin Haptocorrin Divalent metal transporter 1 Divalent metal transporter 2 None 26. The mutations/changes that convert proto-oncogene to oncogene include all except: Promoter insertion Enhancer deletion Gene amplification Point mutation None 27. Berry aneurysm occurs due to: Arterial internal elastic lamina defect Adventitia defect Endothelial layer defect Endothelial injury of the vessel due to HTN None 28. Hepcidin inhibits iron transfer from the enterocyte to the plasma by binding to. Ferroportin Transferrin Divalent metal transporter Ferritin None 29. Which of the following about you T-cells is incorrect: Need antigen processing and presentation for it recognition Provide protection against mycobacteria Direct killing of infected macrophages Kills extracellular bacteria by granulysin and perforin None 30. Which of the following is not true regarding the procedure done using the instrument given in the image below? Breath-holding is required Contraindicated if the platelet count <40,000 Procedure can be done in both lateral & prone positions Diagnosing an infiltrative or granulomatous disease None 31. Ciliocytophthoria is seen in: Kartagener syndrome Situs inversus Cystic fibrosis Acute respiratory infection None 1 out of 31 You Have Successfully Practiced Pathology AIIMS 2019 Time's up
