Solve Pharmacology INICET 2021 1. Which of the following is not an off-label use of risperidone? Bipolar disorder OCD PTSD Dementia None 2. Inhaled Nitric oxide is approved for treatment of Pulmonary hypertension Labile hypertension Treatment of resistant migraine Resistant Parkinson's disease None 3. The elimination rate constant of a drug is 0.05/hr. What is its half-life? 20.8 hours 9.8 hours 13.8 hours 6.9 hours None 4. Nivolumab is used as a checkpoint inhibitor in Retinoblastoma Pleuropulmonary blastoma Medulloblastoma Hodgkin's lymphoma None 5. A patient is on phenytoin for a seizure disorder. He was prescribed sucralfate 4 times a day for peptic ulcers. What should be the minimum duration of time between consumption of these drugs? 30 minutes 60 minutes 90 minutes 120 minutes None 6. Antimicrobial combinations are used in all except Malaria Intra-abdominal infections Tuberculosis Gonorrhea None 7. Category A, B, C, D, X in drug classification are indicative of which of the following? Dose adjustment in renal failure As per safety or therapeutic index Cost ratio from cheap to expensive Safety in pregnancy None 8. What would happen to the half-life and plasma concentration of a drug which follows first-order kinetics, if the dose is doubled? Half-life remains the same and plasma concentration doubles Half-life doubles and plasma concentration remains the same Half-life and plasma concentration doubles Half-life and plasma concentration remains the same None 9. Identify the false statement regarding suicidal inhibition. The binding of the enzyme to the substrate analog is irreversible They are enzyme-specific and used in rational drug design The inhibitor can bind with any site resulting in suicidal inhibition The inhibitor forms a product with the enzyme and the product inhibits it None 10. Which of the following is false about the selection of essential drugs? Fixed drug combination is preferred over single drugs Cost to benefit has to be considered Adequate safety profile needs to be established Disease prevalence is considered None 11. A 36-year-old man with hypertension is diagnosed with stage 4 chronic kidney disease, with an eGFR of Metolazone Chlorthalidone Chlorothiazide Hydrochlorothiazide None 12. The dose at which dopamine acts on beta 1 receptors is 2-10 mcg/kg/min 10-20 mcg/kg/min <2 mcg/kg/min >20 mcg/kg/min None 13. A patient who was diagnosed with epilepsy was put on retigabine TDS. Now phenytoin is being added. Which of the following changes should be made to retigabine? Decrease the dose Stop retigabine and start on carbamazepine Stop the drug Increase the dose None 14. Which of the following is the incorrect statement regarding clomiphene citrate? Causes mono follicular development Inhibits negative feedback on GnRH Can be used with gonadotropin Causes endometrial thinning None 15. What is the mechanism of action of remdesevir? RNA-dependent RNA polymerase inhibition RNA-dependent DNA polymerase inhibition Entry inhibition Fusion inhibition None 16. A patient with history of ischemic stroke was started on clopidogrel. However, she had another attack of stroke after 6 months. Which of the following is likely to be responsible for the failure of clopidogrel in this patient? Upregulation of CYP1A1 Downregulation of CYP2C19 Downregulation of CYP2E1 Downregulation of CYP2D6 None 17. Administration of which of the following drugs would increase the bioavailability of saquinavir? Cimetidine Ganciclovir Ritonavir Vitamin C None 18. The table below gives the AUC of drug B alone and that of drug B when combined with another drug A. If the p value is     Drug A reduces the first-pass metabolism of Drug B Drug A decreases intestinal absorption of Drug B Drug A increases renal elimination of Drug B Drug A increases the metabolism of Drug B None 19. Which of the following can be given for long term management of obesity? Sibutramine Metformin Liraglutide Fenfluramine None 20. What is the mechanism of action of cyclosporine? Inhibition of calcineurin AMP kinase stimulation IMP dehydrogenase inhibition Dihydro-orotate dehydrogenase inhibition None 21. Anionic and weakly acidic drugs bind to which of the following? Albumin Globulin Alpha-1 glycoprotein Lipoprotein None 22. A HIV-positive woman on ART was prescribed ergotamine for a migraine attack 4 days back. She presented with complaints that she is unable to feel her legs from the mid-thigh to her toes, for the past two days. The angiography image is given below. What is the likely diagnosis? Ergotism Polyradicular neuropathy Atherosclerosis Herniated disc None 23. A 15-month-old boy was diagnosed with Hemophilus influenza meningitis. The initial treatment plan was to start on ampicillin but later was shifted to ceftriaxone. What could be the probable reason? Easier to administer IV ceftriaxone than IV ampicillin Hemophilus alters penicillin-binding protein sites, hence resistant to ampicillin Hemophilus produces beta-lactamase, hence resistant to ampicillin Cotrimoxazole is the drug of choice, but patient is allergic to sulfa drugs None 24. Topiramate is used for Treatment of Lennox Gastaut syndrome Treatment of migraine Treatment of dementia Prophylaxis of ADHD None 25. A patient who is a known case of cirrhosis of the liver presents with abdominal distension and swelling of the lower limbs. The preferred diuretic for this patient would be Eplerenone Triamterene Chlorthalidone Furosemide None 26. Which of the following is incorrectly matched? Andexanet alfa: Rivaroxaban Andexanet alfa: Edoxaban Ciraparantag: Fondaparinux Idarucizumab : Dabigatran None 27. Which of the following is the most effective drug in smoking cessation? Buspirone SR Varenicline Rimonabant Nicotine gum None 28. A 60-year-old man was brought to the hospital with complaints of dizziness and breathlessness. During his physical examination, you notice the following discoloration over his face. He is presently being treated with amiodarone, metoprolol, verapamil, lisinopril, and amlodipine. Which of the following drugs is most likely responsible? Amlodipine Amiodarone Verapamil Metoprolol None 29. The anti-epileptic drugs which can also be used for the treatment of neuropathic pain are Pregabalin Carbamazepine Lamotrigine Gabapentin 1, 3 and 4 1, 2 and 3 1, 2 and 4 2 and 4 only None 30. Which of the following is a centrally-acting opioid antitussive? Diphenoxylate Levopropoxyphene Levorphanol Ambroxol None 31. Which of the following is a novel anti-depressant? Lurasidone Asenapine Vilazodone Blonanserin None 1 out of 31 Time's up
